FEATURES OF THE COURSE OF COVID-19 IN PATIENTS WITH ACUTE KIDNEY INJURY
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Abstract
Resume. Introduction. In the modern era, COVID-19 is the biggest challenge facing doctors and scientists round the world. SARS-CoV-2 is a multisystem infection that is not limited to lung damage and has an mmuno-mediated effect of negative effects on organs and systems, including the kidneys. To date, there is no precise understanding of the pathogenesis of nephrological disorders in patients with COVID-19. atients with chronic disease kidney diseases (CKD) are a group of particularly high risk of COVID-19 infection and high mortality in the development of the disease. OBJECTIVE: to evaluate the features of the course of the new coronavirus infection (COVID-19) in patients with acute kidney injury and terminal renal insufficiency. PATIENTS AND METHODS. Clinical, laboratory, and instrumental parameters were studied in 119 patients (67 men and 52 women) diagnosed with COVID-19. The average age of the patients was 63.1±1.7 years. All patients were divided into two groups: group 1 – patients with CKD and HD, Group 2 – patients with newly diagnosed kidney damage due to coronavirus infection (COVID-19). Statistical data analysis was performed using the IBM SPSS Statistics 21.0 software package (USA) (Russified version). results. As a result of the study, it was found that in the clinical picture of patients with COVID-19, suffering from CKD and undergoing hemodialysis, was 2 times more likely to have a symptom such as myalgia, was the percentage of arterial blood hemoglobin saturation with oxygen (SaO2,%) is significantly lower compared with patients with newly diagnosed kidney damage on the background of infection. The duration of the temperature reaction during the disease was 5 times longer than in patients without CKD. Although the incidence of lung damage in patients of both groups was identical, mortality was significantly higher in the group of patients with CKD.
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